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BIOMEDE 474: INTRODUCTION TO TISSUE ENGINEERING Fall 2021
Journal Review Assignment (10% of your final grade)
Due December 13, 2021 before 11:59 PM
The ability to read and distill papers in the primary scientific literature into short scientific reviews in your
own words is a critical skill and common practice in both academia and industry. For this assignment,
please pick from one of the 30 journal articles from the recent scientific literature listed below (all in the
broad area of tissue engineering, but broken down into more specific categories to help you guide your
selection). Once you select your paper, find it online (via PubMed or Google Scholar), download it, read it,
and then critically evaluate it. Your assignment is to then write a concise review/critique of the paper
summarizing the key findings.
(Note: If you REALLY want to read and review another paper of your choosing, you are welcome to do so.
However, you MUST get it approved by me in advance.)
Here are some guidelines.
• Your review should be concise! Please, no longer than 4 typed pages (single-sided, single-spaced,
Arial 11 pt. font with 1-inch margins).
• Your review should summarize the key methods utilized by the authors that led to their findings and
conclusions. However, you DO NOT need to summarize EVERY SINGLE EXPERIMENT or figure in
• Your review should include your interpretation of the significance of the findings, and place the paper’s
results in a larger context. In other words, your review should assess how the results from the paper
impact a particular field or fields. This may require you to read (or at least be familiar with) other papers
in the field (for example, some of those we discussed in class or you read for the class).
Format: 4 pages maximum, single spaced, single sided, Arial 11-pt font, 1-inch margins
Executive Summary, describing the paper in your own words (0.5 page)
Summarize the key materials and methods (~0.5-1 page)
Summarize the data/results presented in the figures (~1 page)
Discussion (~1-1.5 page):
• The significance of the findings in your own words, putting this work into larger context
• Any weaknesses or concerns you have about the paper, how you might improve the paper, or the next
steps you would take in a subsequent study.
References (not required, but please cite any other references if you used any)
The assignment will be graded on a 100-pt scale according to the following breakdown:
• Executive summary (10 points)
• Accurate assessment of the key methods (20 points)
• Accurate assessment of the key results (20 points)
• Discussion of the significance of the paper in your own words (20 points)
• Discussion of any weaknesses or concerns you have about the paper, how you might improve the
paper, or the next steps you would take in a subsequent study (20 points)
• Conciseness and adherence to format (10 points)
List of papers from which you can choose
1. Grigoryan, B., S.J. Paulsen, D.C. Corbett, D.W. Sazer, C.L. Fortin, A.J. Zaita, P.T. Greenfield, N.J.
Calafat, J.P. Gounley, A.H. Ta, F. Johansson, A. Randles, J.E. Rosenkrantz, J.D. Louis-Rosenberg,
P.A. Galie, K.R. Stevens, and J.S. Miller, Multivascular networks and functional intravascular
topologies within biocompatible hydrogels. Science, 2019. 364(6439): p. 458-464.
2. Kolesky, D.B., K.A. Homan, M.A. Skylar-Scott, and J.A. Lewis, Three-dimensional bioprinting of thick
vascularized tissues. Proc Natl Acad Sci U S A, 2016. 113(12): p. 3179-84.3. Zhang, B., M. Montgomery, M.D. Chamberlain, S. Ogawa, A. Korolj, A. Pahnke, L.A. Wells, S. Massé,
J. Kim, L. Reis, A. Momen, S.S. Nunes, A.R. Wheeler, K. Nanthakumar, G. Keller, M.V. Sefton, and M.
Radisic, Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct
surgical anastomosis. Nat Mater, 2016. 15(6): p. 669-78.
4. Li, S., L.R. Nih, H. Bachman, P. Fei, Y. Li, E. Nam, R. Dimatteo, S.T. Carmichael, T.H. Barker, and T.
Segura, Hydrogels with precisely controlled integrin activation dictate vascular patterning and
permeability. Nat Mater, 2017. 16(9): p. 953-961.
5. Torres, A.L., S.J. Bidarra, M.T. Pinto, P.C. Aguiar, E.A. Silva, and C.C. Barrias, Guiding morphogenesis
in cell-instructive microgels for therapeutic angiogenesis. Biomaterials, 2017. 154: p. 34-47.
6. Lin, R.Z., C.N. Lee, R. Moreno-Luna, J. Neumeyer, B. Piekarski, P. Zhou, M.A. Moses, M. Sachdev,
W.T. Pu, S. Emani, and J.M. Melero-Martin, Host non-inflammatory neutrophils mediate the
engraftment of bioengineered vascular networks. Nat Biomed Eng, 2017. 1.
7. Mirabella, T., J.W. MacArthur, D. Cheng, C.K. Ozaki, Y.J. Woo, M. Yang, and C.S. Chen, 3D-printed
vascular networks direct therapeutic angiogenesis in ischaemia. Nat Biomed Eng, 2017. 1.
8. Wei, Z., R. Schnellmann, H.C. Pruitt, and S. Gerecht, Hydrogel Network Dynamics Regulate Vascular
Morphogenesis. Cell Stem Cell, 2020.
9. Arakawa, C.K., B.A. Badeau, Y. Zheng, and C.A. DeForest, Multicellular Vascularized Engineered
Tissues through User-Programmable Biomaterial Photodegradation. Adv Mater, 2017. 29(37).
10. Graney, P.L., S. Ben-Shaul, S. Landau, A. Bajpai, B. Singh, J. Eager, A. Cohen, S. Levenberg, and
K.L. Spiller, Macrophages of diverse phenotypes drive vascularization of engineered tissues. Sci Adv,
2020. 6(18): p. eaay6391.
11. Mehrban, N., C. Pineda Molina, L.M. Quijano, J. Bowen, S.A. Johnson, J. Bartolacci, J.T. Chang, D.A.
Scott, D.N. Woolfson, M.A. Birchall, and S.F. Badylak, Host macrophage response to injectable
hydrogels derived from ECM and α-helical peptides. Acta Biomater, 2020. 111: p. 141-152.
12. Springer, N.L., N.M. Iyengar, R. Bareja, A. Verma, M.S. Jochelson, D.D. Giri, X.K. Zhou, O. Elemento,
A.J. Dannenberg, and C. Fischbach, Obesity-Associated Extracellular Matrix Remodeling Promotes a
Macrophage Phenotype Similar to Tumor-Associated Macrophages. Am J Pathol, 2019. 189(10): p.
13. Raimondo, T.M. and D.J. Mooney, Functional muscle recovery with nanoparticle-directed M2
macrophage polarization in mice. Proc Natl Acad Sci U S A, 2018. 115(42): p. 10648-10653.
14. Baker, B.M., B. Trappmann, W.Y. Wang, M.S. Sakar, I.L. Kim, V.B. Shenoy, J.A. Burdick, and C.S.
Chen, Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered
fibrillar microenvironments. Nat Mater, 2015. 14(12): p. 1262-8.
15. Chaudhuri, O., L. Gu, D. Klumpers, M. Darnell, S.A. Bencherif, J.C. Weaver, N. Huebsch, H.P. Lee, E.
Lippens, G.N. Duda, and D.J. Mooney, Hydrogels with tunable stress relaxation regulate stem cell fate
and activity. Nat Mater, 2015.
16. Yang, C., M.W. Tibbitt, L. Basta, and K.S. Anseth, Mechanical memory and dosing influence stem cell
fate. Nat Mater, 2014. 13(6): p. 645-52.
17. Shin, J.W., A. Buxboim, K.R. Spinler, J. Swift, D.A. Christian, C.A. Hunter, C. Leon, C. Gachet, P.C.
Dingal, I.L. Ivanovska, F. Rehfeldt, J.A. Chasis, and D.E. Discher, Contractile forces sustain and
polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell, 2014. 14(1): p. 81-93.
18. Dye, B.R., R.L. Youngblood, R.S. Oakes, T. Kasputis, D.W. Clough, J.R. Spence, and L.D. Shea,
Human lung organoids develop into adult airway-like structures directed by physico-chemical
biomaterial properties. Biomaterials, 2020. 234: p. 119757.
19. Petersen, T.H., E.A. Calle, L. Zhao, E.J. Lee, L. Gui, M.B. Raredon, K. Gavrilov, T. Yi, Z.W. Zhuang,
C. Breuer, E. Herzog, and L.E. Niklason, Tissue-engineered lungs for in vivo implantation. Science,
2010. 329(5991): p. 538-41.
Nerve20. Schwartz, M.P., Z. Hou, N.E. Propson, J. Zhang, C.J. Engstrom, V. Santos Costa, P. Jiang, B.K.
Nguyen, J.M. Bolin, W. Daly, Y. Wang, R. Stewart, C.D. Page, W.L. Murphy, and J.A. Thomson, Human
pluripotent stem cell-derived neural constructs for predicting neural toxicity. Proc Natl Acad Sci U S A,
2015. 112(40): p. 12516-21.
21. Thompson, R.E., J. Pardieck, L. Smith, P. Kenny, L. Crawford, M. Shoichet, and S. Sakiyama-Elbert,
Effect of hyaluronic acid hydrogels containing astrocyte-derived extracellular matrix and/or V2a
interneurons on histologic outcomes following spinal cord injury. Biomaterials, 2018. 162: p. 208-223.
22. Stevens, K.R., M.A. Scull, V. Ramanan, C.L. Fortin, R.R. Chaturvedi, K.A. Knouse, J.W. Xiao, C. Fung,
T. Mirabella, A.X. Chen, M.G. McCue, M.T. Yang, H.E. Fleming, K. Chung, Y.P. de Jong, C.S. Chen,
C.M. Rice, and S.N. Bhatia, In situ expansion of engineered human liver tissue in a mouse model of
chronic liver disease. Sci Transl Med, 2017. 9(399).
23. Lee, H., W. Han, H. Kim, D.H. Ha, J. Jang, B.S. Kim, and D.W. Cho, Development of Liver
Decellularized Extracellular Matrix Bioink for Three-Dimensional Cell Printing-Based Liver Tissue
Engineering. Biomacromolecules, 2017. 18(4): p. 1229-1237.
24. Weaver, J.D., D.M. Headen, J. Aquart, C.T. Johnson, L.D. Shea, H. Shirwan, and A.J. Garcia,
Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites.
Sci Adv, 2017. 3(6): p. e1700184.
25. Coronel, M.M., K.E. Martin, M.D. Hunckler, G. Barber, E.B. O’Neill, J.D. Medina, E. Opri, C.A. McClain,
L. Batra, J.D. Weaver, H.S. Lim, P. Qiu, E.A. Botchwey, E.S. Yolcu, H. Shirwan, and A.J. García,
Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival. Sci Adv, 2020.
6(35): p. eaba5573.
26. Gjorevski, N., N. Sachs, A. Manfrin, S. Giger, M.E. Bragina, P. Ordóñez-Morán, H. Clevers, and M.P.
Lutolf, Designer matrices for intestinal stem cell and organoid culture. Nature, 2016. 539(7630): p. 560-
Primary scientific literature
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